Patients with serious COVID-19-related lung damage have been observed to have higher than normal levels of angiotensin II in their bodies. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Children aged 6 years and older can take it, but only to treat high blood pressure. Losartan and other ARBs function by inhibiting the angiotensin converting enzyme type I receptor, also known as the ACE1 receptor, and therefore block downstream proinflammatory effects of angiotensin II, mediated by the renin-angiotensin-aldosterone system (RAAS) (). Side Effects. Tignanelli, C, Ingraham N, Sparks M, et al. Drug information: 12 - Cardiovascular medicines 12.3 - Antihypertensive medicines 12.4 - Medicines used in heart failure. His love of Listing a study does not mean it has been evaluated by the U.S. Federal Government. Losartan, however, blocks the action of the hormone. Losartan work by blocking the action of a natural chemical called angiotensin II. In other words, don’t try this at home without a doctor’s monitoring and guidance. The names in this area are pretty confusing, for one thing, and if you’re not familiar with the tangled feedback loops that you get in human biology, it all starts to look like a … However, without known who has it and who doesn’t, these measures might not be enough to prevent the virus from wreaking havoc for the foreseeable future. Skip to main content Accessibility help We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Mode of administration in addition to being given orally, could be in the form of a nasal spray. The largest Chinese study with 44,672 confirmed cases of Covid-19 shows a high overall case fatality rate (CFR) of 2.3% [2]. Losartan Information for Healthcare Professionals. Preventing a COVID-19 infection isn’t beneficial if that treatment produces potentially life-threatening side effects anyway. There’s quite a bit of confusion around the ACE proteins and coronavirus infection, and I can see why. Up to six weeks may be required for the full effects to occur. Losartan is used to treat high blood pressure (hypertension). Losartan is not a receptor, but it does block a chemical (angiotensin II) from binding to a receptor (AT1), which lowers blood pressure. Losartan is not a receptor, but it does block a chemical (angiotensin II), from binding to a receptor, type 1 angiotensin 2 (AT1), which lowers blood pressure. Losartan and Telmisartan strongly bind to the AT1 receptors more than Valsartan [2]. Your doctor may prescribe losartan if you've tried taking similar blood pressure-lowering medicines such as ramipril and lisinopril in the past, but had to stop taking them because of side effects such as a dry, irritating cough. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Some animal studies found losartan beneficial at reducing severe simulated lung injury in mice exposed to other viruses, such as SARS. Losartan can be taken by adults aged 18 years and over. reporting is second only to his gaming addiction. SPH biostatistics researchers are leading the design, conduct, and data analysis of studies to see if losartan can … For people already taking losartan or any other ARB, the advice from the medical community is to keep taking it unless your doctor tells you otherwise. My own GP told me that Losartan was known for its lack of side effects, and generally held the view that it was a safe bet, especially if being taken alongside other medications. Last updated on March 30, 2020. Scientists from the University of Minnesota are testing the blood pressure drug losartan to see if it can prevent COVID-19 infection or reduce symptoms. Although not all of these side effects may occur, if they do occur they may need medical attention. The novel coronavirus interferes with the mechanism that regulates the hormone’s level; this leads to high blood pressure and lung damage. CONCLUSION: In this pilot study we demonstrate that losartan was well-tolerated among hospitalized patients with COVID-19 and hypertension. CEBM March 23, 2020. Studies that were conducted include: We do not know whether the supposed benefits of ARBs during an episode of infection with SARS-CoV-2 outweigh the potential harms. Therefore, use of the former could be suitable in treatment of novel corona virus (Wuhan, China) infections. Experts worldwide are experimenting with drugs to treat COVID-19. Does Losartan block the receptor used by the Coronavirus? Medically reviewed by Carmen Fookes, BPharm. Trial Sites Trials are currently underway, but it may be weeks before we know the results. It may be used alone or in addition to other blood pressure medication. While we wait to hear the results of these trials from scientists it’s important that we all follow social distancing recommendations and avoid large gatherings of people. Losartan helps to block those actions by angiotensin II in people with hypertension. Losartan for Patients With COVID-19 Requiring Hospitalization. It is taken by mouth. Losartan (Cozaar) belongs to a class of medicines called Angiotensin Receptor Blockers (ARBs), also known as Angiotensin II receptor antagonists. We also demonstrate the feasibility of patient recruitment and the appropriate parameters to assess the outcomes and safety of losartan initiation or continuation, which provides a framework for future randomized clinical trials. The Lancet. Disease: Coronavirus disease 2019 (COVID-19); Virus strain: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); First case: December 1, 2019; Origin: Wuhan, Hubei, China; Symptoms: Symptoms may appear 2-14 days after exposure to the virus. In addition to testing the blood pressure drug losartan, scientists are testing hydroxychloroquine, a malaria medication, to see if it, too, can help prevent infections or shorten recovery times. This video contains a case report of a patient with COVID19 whose ARDS could be limited and treated with low dose of losartan. The COVID-19 pandemic is spreading at an exponential rate, with millions of people across the globe at risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The researchers hope this will counteract the effects of the excess angiotensin II and prevent lung damage in COVID-19 patients. Called the angiotensin-converting enzyme 2, or ACE2 “receptor,” the protein provides the entry point for the coronavirus to hook into and infect a wide range of human cells. Losartan, therefore, works on the renin-angiotensin system (RAS) which is a hormonal system that regulates blood pressure. SARS was also a coronavirus and is like SARS-CoV-2, the virus that causes COVID-19. Where can I buy an at-home test kit for COVID-19 (coronavirus)?   Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. What's the difference between Bacteria and Viruses? March 16: updated original description of SARS-CoV-2, Links to outpatient and inpatient clinical trials using losartan in COVID-19, added explainer video from Med Rants. have similar effects to ACE inhibitors and may also be useful in treating COVID-19. 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